Gja1^tm7(Gja2)Kwi
Targeted Allele Detail

Summary

• Symbol: Gja1^tm7(Gja2)Kwi
• Name: gap junction protein, alpha 1; targeted mutation 7, Klaus Willecke
• MGI ID: MGI:3763136
• Synonyms: Cx43²⁶
• Gene: Gja1 Location: Chr10:56253297-56266519 bp, + strand Genetic Position: Chr10, 28.64 cM
• Alliance: Gja1^tm7(Gja2)Kwi page

Tubuli seminiferi and ductuli epididymidis of wild type and Gja1^tm7(Gja2)Kwi/Gja1^tm7(Gja2)Kwi mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126511
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced with that of Gja2 and a neo cassette flanked by FRT sites. The neo cassette was subsequently removed by Flp-mediated recombination following a cross to Tg(ACTFLPe)9205Dym mice. The replacement of protein products was confirmed by western blot analysis on protein extracts from heart lysates. (J:126511)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gja1 Mutation: 60 strains or lines available

References

• Original: J:126511 Winterhager E, et al., Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart. BMC Dev Biol. 2007;7:26
• All: 1 reference(s)