Grk2^tm1Gwd
Targeted Allele Detail

Summary

• Symbol: Grk2^tm1Gwd
• Name: G protein-coupled receptor kinase 2; targeted mutation 1, Gerald W Dorn II
• MGI ID: MGI:3763199
• Synonyms: GRK2^f
• Gene: Grk2 Location: Chr19:4336029-4356250 bp, - strand Genetic Position: Chr19, 3.98 cM
• Alliance: Grk2^tm1Gwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126501
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 through 6 were flanked by loxP sites and a neo cassette flanked by frt sites was inserted 5' of exon 3. The neo cassette was removed by Flp-mediated recombination following a cross to Gt(ROSA)26Sor^tm1(FLP1)Dym mice. Southern blot analysis was performed to confirm the insertions. (J:126501)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grk2 Mutation: 37 strains or lines available

References

• Original: J:126501 Matkovich SJ, et al., Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circ Res. 2006 Oct 27;99(9):996-1003
• All: 35 reference(s)