Grk2^tm1.1Gwd
Targeted Allele Detail

Summary

• Symbol: Grk2^tm1.1Gwd
• Name: G protein-coupled receptor kinase 2; targeted mutation 1.1, Gerald W Dorn II
• MGI ID: MGI:3763201
• Synonyms: GRK2^-
• Gene: Grk2 Location: Chr19:4336029-4356250 bp, - strand Genetic Position: Chr19, 3.98 cM
• Alliance: Grk2^tm1.1Gwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126501
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 3 through 6 were removed by cre-mediated recombination following a cross Tg(EIIa-cre)C5379Lmgd mice. The absence of protein product was confirmed by western blot analsysis on protein extracts from whole E9.5 embryos. (J:126501)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grk2 Mutation: 37 strains or lines available

References

• Original: J:126501 Matkovich SJ, et al., Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circ Res. 2006 Oct 27;99(9):996-1003
• All: 2 reference(s)