Ghrl^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Ghrl^tm1Lex
• Name: ghrelin; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3763213
• Gene: Ghrl Location: Chr6:113693080-113696841 bp, - strand Genetic Position: Chr6, 52.84 cM, cytoband E3
• Alliance: Ghrl^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126636
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 285 bp fragment including the coding region of exon 2 up to exon 3 was replaced with a LacZ-neo cassette. RT-PCR analysis confirms the absence of transcript from the stomach, jejunum, brain, and blood in homozygous mice. (J:126636)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghrl Mutation: 12 strains or lines available

References

• Original: J:126636 De Smet B, et al., Energy homeostasis and gastric emptying in ghrelin knockout mice. J Pharmacol Exp Ther. 2006 Jan;316(1):431-9
• All: 1 reference(s)