Tacc3^tm1.2Tno
Targeted Allele Detail

Summary

• Symbol: Tacc3^tm1.2Tno
• Name: transforming, acidic coiled-coil containing protein 3; targeted mutation 1.2, Tetsuo Noda
• MGI ID: MGI:3763219
• Synonyms: Tacc3^D
• Gene: Tacc3 Location: Chr5:33815472-33836339 bp, + strand Genetic Position: Chr5, 17.83 cM
• Alliance: Tacc3^tm1.2Tno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126471
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The genomic region between intron 4 and 5 was removed by cre-mediated recombination following the electroporation of embryonic stem cells with a transient cre-expression construct. The absence of protein product was confirmed by western blot analysis on protein extracted from whole E9.5 embryos. (J:126471)

Tumor Data

List all tumor models in MMHCdb carrying Tacc3^tm1.2Tno

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tacc3 Mutation: 29 strains or lines available

References

• Original: J:126471 Yao R, et al., TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton. Cancer Sci. 2007 Apr;98(4):555-62
• All: 2 reference(s)