Tg(Itgax-cre)1-1Reiz
Transgene Detail

Summary

• Symbol: Tg(Itgax-cre)1-1Reiz
• Name: transgene insertion 1-1, Boris Reizis
• MGI ID: MGI:3763248
• Synonyms: Cd11c-cre, CD11cCre, CD11cCre^T
• Transgene: Tg(Itgax-cre)1-1Reiz Location: unknown
• Alliance: Tg(Itgax-cre)1-1Reiz page

Lupus-like autoimmune disease in Lyn^tm1Sor/Lyn^tm1Sor and Lyn^tm1.1Calo/Lyn^tm1.1Calo Top2a^{Gt(PST14568)Mfgc}/0 mice

Show the 3 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Itgax-cre)1-1Reiz expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Itgax (MGI:96609)

• Mutation details: A transgenic construct containing sequence encoding cre recombinase under the control of the mouse integrin alpha X (Cd11c) promoter, and a bovine growth hormone poly A signal sequence, was introduced into B6CBAF1/J donor eggs. BAC clone RP24-361C4 (BACPAC Resources) containing the Itgax (Cd11c) gene but lacking the 5' end of the adjacent Itgam gene, was modified by ET recombination to generated the transgene construct. Founder line 1-1 was consequently established. Cre recombinase expression is detected in CD8-, CD8+ dendritic cells, tissue derived dendritic cells from lymph nodes, lung and epidermis and plasmacytoid dendritic cells. Background recombination is detected in lymphocytes (<10%) and myeloid cells (<1%). (J:125869)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Itgax (mouse) Summary of all recombinase alleles driven by Itgax. Comparative matrix view of recombinase activities Alliance mouse Itgax gene page

Disease models

Expression

In Mice Carrying this Mutation:

9 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available

References

• Original: J:125869 Caton ML, et al., Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J Exp Med. 2007 Jul 9;204(7):1653-64
• All: 675 reference(s)