Tead4^tm1.1Bnno
Targeted Allele Detail

Summary

• Symbol: Tead4^tm1.1Bnno
• Name: TEA domain family member 4; targeted mutation 1.1, Andres Buonanno
• MGI ID: MGI:3763362
• Synonyms: Tead4^-, Tead^tm
• Gene: Tead4 Location: Chr6:128204106-128277776 bp, - strand Genetic Position: Chr6, 62.92 cM
• Alliance: Tead4^tm1.1Bnno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126338
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was removed by cre-mediated recombination. This exon codes for the TEA DNA-binding domain. Absence of transcript in all normally expressing tissues was confirmed by RT-PCR. (J:126338)

Expression

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tead4 Mutation: 75 strains or lines available

References

• Original: J:126338 Yagi R, et al., Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development. Development. 2007 Nov;134(21):3827-36
• All: 4 reference(s)