Tead2^tm1.1Mldp
Targeted Allele Detail

Summary

• Symbol: Tead2^tm1.1Mldp
• Name: TEA domain family member 2; targeted mutation 1.1, Melvin DePamphilis
• MGI ID: MGI:3763367
• Synonyms: Tead2^-
• Gene: Tead2 Location: Chr7:44865216-44882892 bp, + strand Genetic Position: Chr7, 29.19 cM, cytoband B5
• Alliance: Tead2^tm1.1Mldp page

Exencephaly in Tead2^tm1.1Mldp/Tead2^tm1.1Mldp embryos at E13.5

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127233
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The enhancer located upstream of exon 2, exon 2 and exon 3 were removed by cre-mediated recombination. These regions are responsible for encoding the N-terminal 99 amino acids of the protein thereby removing the translation initiation site and 82% of the TEA domain. Reduction in transcript production was confirmed by northern blot analysis on RNA extracted from lungs. (J:127233)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tead2 Mutation: 34 strains or lines available

References

• Original: J:127233 Kaneko KJ, et al., Transcription factor TEAD2 is involved in neural tube closure. Genesis. 2007 Sep;45(9):577-87
• All: 2 reference(s)