Adgra3^tm1Rafi
Targeted Allele Detail

Summary

• Symbol: Adgra3^tm1Rafi
• Name: adhesion G protein-coupled receptor A3; targeted mutation 1, Shahin Rafii
• MGI ID: MGI:3763371
• Synonyms: Gpr125^lacZ
• Gene: Adgra3 Location: Chr5:50117293-50216338 bp, - strand Genetic Position: Chr5, 26.85 cM
• Alliance: Adgra3^tm1Rafi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126330
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 16 through exon 18 was replaced with lacZ to create a fusion product. The predicted fusion protein contains the ECD1, first transmembrane domain and part of the first intracellular loop fused to beta-galactosidase. Beta-galactosidase expression was confirmed in the seminiferous tubules in the first layer of cells adjacent to the basement membrane. (J:126330)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgra3 Mutation: 71 strains or lines available

References

• Original: J:126330 Seandel M, et al., Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature. 2007 Sep 20;449(7160):346-50
• All: 3 reference(s)