Ptprb^tm1Gdy
Targeted Allele Detail

Summary

• Symbol: Ptprb^tm1Gdy
• Name: protein tyrosine phosphatase receptor type B; targeted mutation 1, George D Yancopoulos
• MGI ID: MGI:3763454
• Synonyms: VE-PTP^-
• Gene: Ptprb Location: Chr10:116111428-116225440 bp, + strand Genetic Position: Chr10, 64.68 cM, cytoband D2
• Alliance: Ptprb^tm1Gdy page

Angiogenic defects in Ptprb^tm1Gdy/Ptprb^tm1Gdy mouse embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125903
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An 11.8-kb segment of the gene extending from 27 nucleotides in exon 2 through exon 3 was replaced with a beta-gal reporter gene and a loxP-flanked neomycin selection cassette. Quantitative RT-PCR on 9.5 embryos demonstrated no gene expression in homozygotes. Beta-gal expression was observed in the developing cardiovascular system. (J:125903)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprb Mutation: 99 strains or lines available

References

• Original: J:125903 Dominguez MG, et al., Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3243-8
• All: 2 reference(s)