Trhr^tm1Hzg
Targeted Allele Detail

Summary

• Symbol: Trhr^tm1Hzg
• Name: thyrotropin releasing hormone receptor; targeted mutation 1, Hongkui Zeng
• MGI ID: MGI:3763533
• Gene: Trhr Location: Chr15:44059531-44099308 bp, + strand Genetic Position: Chr15, 16.82 cM
• Alliance: Trhr^tm1Hzg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125915
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A retroviral vector containing an SA-stop-IRES-rtTA and floxed neo cassette was inserted between exons 1 and 2. The absence of transcript in the pituitary and brain was confirmed by RT-PCR. (J:125915)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trhr Mutation: 33 strains or lines available

References

• Original: J:125915 Zeng H, et al., Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior. Mol Endocrinol. 2007 Nov;21(11):2795-804
• All: 2 reference(s)