Tg(Alb-PLG)1Dgi
Transgene Detail

Summary

• Symbol: Tg(Alb-PLG)1Dgi
• Name: transgene insertion 1, David Ginsburg
• MGI ID: MGI:3763545
• Transgene: Tg(Alb-PLG)1Dgi Location: unknown
• Alliance: Tg(Alb-PLG)1Dgi page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F1 x (C57BL/6J x SJL/J)F1 or (C57BL/6 x (C57BL/6J x SJL/J)F1)

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-PLG)1Dgi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PLG (5340)

  Plg	(MGI:97620)

• Mutation details: A cassette containing the human PLG cDNA from nucleotide -13 (A of ATG initiation codon as +1) to +2476 (including the entire coding sequence) was followed by the green fluorescent protein (EGFP) coding sequence, preceded by an internal ribosome entry site sequence (IRES) and a bacterial kanamycin-resistant gene (KAN). A chimeric intron with optimized splice signals from the pCI expression vector was placed upstream of the PLG cDNA. Homologous recombination between the transgene targeting construct and the murine Alb BAC was carried out in E. coli, replacing the murine Alb gene (from nucleotide -12 to exon 12) by the transgene cassette. EGFP expression is not detected. (J:120780)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:120780 Sun H, et al., Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science. 2004 Aug 27;305(5688):1283-6
• All: 4 reference(s)