Adm^tm2Unc
Targeted Allele Detail

Summary

• Symbol: Adm^tm2Unc
• Name: adrenomedullin; targeted mutation 2, University of North Carolina
• MGI ID: MGI:3763612
• Synonyms: AM^Duplication
• Gene: Adm Location: Chr7:110226868-110229027 bp, + strand Genetic Position: Chr7, 57.7 cM
• Alliance: Adm^tm2Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125933
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Other
• Mutation details: Using the same homology regions as contained in the targeting vector used to generate Adm^tm1Unc, the gene region and 3.7 kb of the 5' promoter region was duplicated. The insertion was confirmed by Southern blot analysis. The increased transcript and protein production was confirmed by RT-PCR and western blot analysis, respectively, of kidney tissue. (J:125933)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adm Mutation: 13 strains or lines available

References

• Original: J:125933 Caron K, et al., Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3420-5
• All: 1 reference(s)