Adamts13^tm1Myta
Targeted Allele Detail

Summary

• Symbol: Adamts13^tm1Myta
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 13; targeted mutation 1, Toshiyuki Miyata
• MGI ID: MGI:3763820
• Synonyms: Adamts13^-
• Gene: Adamts13 Location: Chr2:26863428-26899640 bp, + strand Genetic Position: Chr2, 19.14 cM
• Alliance: Adamts13^tm1Myta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125786
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exons 3-6 that encode the catalytic domain of the protein were replaced with a neomycin resistance cassette. Elimination of gene expression in homozygotes was confirmed by quantitative RT PCR on liver RNA and by the lack of enzymatic activity of the gene product in plasma. (J:125786)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts13 Mutation: 70 strains or lines available

Notes

ES cell line = "R-CMTI-1A" (J:125786)

References

• Original: J:125786 Banno F, et al., Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura. Blood. 2006 Apr 15;107(8):3161-6
• All: 2 reference(s)