Ctsk^tm1(cre)Ska
Targeted Allele Detail

Summary

• Symbol: Ctsk^tm1(cre)Ska
• Name: cathepsin K; targeted mutation 1, Shigeaki Kato
• MGI ID: MGI:3764465
• Synonyms: Cathepsin K-Cre, CatK^Cre, Ctsk^Cre, CtsKCre
• Gene: Ctsk Location: Chr3:95406567-95416673 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Ctsk^tm1(cre)Ska page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127179
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutation: Insertion
• Ctsk^tm1(cre)Ska expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ctsk (MGI:107823)

• Mutation details: A cre recombinase gene and a downstream frt-flanked kanamycin/neomycin resistance gene was inserted into the endogenous ATG start site of the gene, replacing the first four exons. Chimeric mice were crossed with a deleter strain to remove the selection cassette. Cre expression in heterozygotes was detected in mature osteoclasts but not osteoblasts when crossed with a tester strain. (J:127179)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ctsk (mouse) Summary of all recombinase alleles driven by Ctsk. Comparative matrix view of recombinase activities Alliance mouse Ctsk gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsk Mutation: 31 strains or lines available

References

• Original: J:127179 Nakamura T, et al., Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell. 2007 Sep 7;130(5):811-23
• All: 85 reference(s)