Cerk^tm1Yiga
Targeted Allele Detail

Summary

• Symbol: Cerk^tm1Yiga
• Name: ceramide kinase; targeted mutation 1, Yasuyuki Igarashi
• MGI ID: MGI:3764485
• Synonyms: CerK-null
• Gene: Cerk Location: Chr15:86023329-86070342 bp, - strand Genetic Position: Chr15, 40.52 cM
• Alliance: Cerk^tm1Yiga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127354
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 6 of the gene, which encodes for a diacylglycerol kinase-like catalytic domain. No enzymatic activity of the gene product was detected in brain tissue from homozygotic mice. (J:127354)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cerk Mutation: 26 strains or lines available

References

• Original: J:127354 Mitsutake S, et al., The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells. Biochem Biophys Res Commun. 2007 Nov 23;363(3):519-24
• All: 3 reference(s)