Cyp3a13^tm1Nki
Targeted Allele Detail

Summary

• Symbol: Cyp3a13^tm1Nki
• Name: cytochrome P450, family 3, subfamily a, polypeptide 13; targeted mutation 1, The Netherlands Cancer Institute
• MGI ID: MGI:3764486
• Synonyms: Cyp3a13^tm1728Arte, Cyp3a13^tm1Ahs
• Gene: Cyp3a13 Location: Chr5:137891194-137919881 bp, - strand Genetic Position: Chr5, 76.89 cM
• Alliance: Cyp3a13^tm1Nki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127366
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, exon 2 and the putative promoter region were replaced with a PGK-hygromycin cassette. Authors state that this is a null allele. (J:127366)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Cyp3a13 Mutation: 39 strains or lines available

References

• Original: J:127366 van Herwaarden AE, et al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J Clin Invest. 2007 Nov;117(11):3583-92
• All: 11 reference(s)