Pcdh10^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Pcdh10^tm1Lex
• Name: protocadherin 10; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3764488
• Gene: Pcdh10 Location: Chr3:45332833-45389014 bp, + strand Genetic Position: Chr3, 20.35 cM, cytoband C
• Alliance: Pcdh10^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127418
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire first exon after the initiation site was replaced with a lacZ-neo cassette. Expression of the lacZ gene was confirmed by beta-galactosidase assay to be restricted to the soma and axons of striatal neurons. (J:127418)

Expression

In Mice Carrying this Mutation:	414 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcdh10 Mutation: 55 strains or lines available

References

• Original: J:127418 Uemura M, et al., OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections. Nat Neurosci. 2007 Sep;10(9):1151-9
• All: 7 reference(s)