Ptch1^tm1Hahn
Targeted Allele Detail

Summary

• Symbol: Ptch1^tm1Hahn
• Name: patched 1; targeted mutation 1, Heidi Hahn
• MGI ID: MGI:3764517
• Synonyms: Ptch^flox
• Gene: Ptch1 Location: Chr13:63656142-63721274 bp, - strand Genetic Position: Chr13, 32.8 cM
• Alliance: Ptch1^tm1Hahn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127207
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 7 and a second loxP site followed by a frt-flanked neo cassette was inserted into intron 9. Insertion was confirmed by Southern blot analysis and PCR genotyping. (J:127207)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptch1^tm1Hahn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptch1 Mutation: 115 strains or lines available

References

• Original: J:127207 Uhmann A, et al., The Hedgehog receptor Patched controls lymphoid lineage commitment. Blood. 2007 Sep 15;110(6):1814-23
• All: 42 reference(s)