Tg(Ins2-CD86)12B70Flv
Transgene Detail

Summary

• Symbol: Tg(Ins2-CD86)12B70Flv
• Name: transgene insertion 12B70, Richard Flavell
• MGI ID: MGI:3764558
• Synonyms: RIP-CD86
• Transgene: Tg(Ins2-CD86)12B70Flv Location: unknown
• Alliance: Tg(Ins2-CD86)12B70Flv page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA/Ca)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-CD86)12B70Flv expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD86 (942)

  Cd86	(MGI:101773)

• Tg(Ins2-CD86)12B70Flv expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The transgenic construct contains the human CD86 gene driven by the rat insulin 2 promoter (RIP). Transgenic protein expression is restricted to the Islets of Langerhans. (J:93555)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:93555 Guerder S, et al., Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes. J Immunol. 1998 Sep 1;161(5):2128-40
• All: 3 reference(s)