Tg(Ins2-Lta)#Flv
Transgene Detail

Summary

• Symbol: Tg(Ins2-Lta)#Flv
• Name: transgene insertion #, Richard Flavell
• MGI ID: MGI:3764659
• Synonyms: RIP-Lta, RIP-LTalpha, RIP-TNFbeta
• Transgene: Tg(Ins2-Lta)#Flv Location: unknown
• Alliance: Tg(Ins2-Lta)#Flv page

Mononuclear cell infiltration in islets of Tg(Ins2-Lta)#Flv/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Lta)#Flv expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lta (MGI:104797)

• Tg(Ins2-Lta)#Flv expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: A construct with the murine Lta (tumor necrosis factor-beta) gene expressed from a 600-bp fragment of the rat insulin 2 promoter (RIP) was injected into fertilized oocytes. Founders 5 (~10 copies), 16 (~100 copies), and 42 (~100 copies) were bred with C57BL/6 mice. Lta RNA was detected in pancreas, kidney and skin of transgenic mice by Northern blot. (J:127705)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127705 Picarella DE, et al., Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10036-40
• All: 7 reference(s)