Bnip3^tm1Gwd
Targeted Allele Detail

Summary

• Symbol: Bnip3^tm1Gwd
• Name: BCL2/adenovirus E1B interacting protein 3; targeted mutation 1, Gerald W Dorn II
• MGI ID: MGI:3764664
• Synonyms: Bnip3^-
• Gene: Bnip3 Location: Chr7:138492565-138511235 bp, - strand Genetic Position: Chr7, 82.95 cM, cytoband F5
• Alliance: Bnip3^tm1Gwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127533
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a floxed neo cassette leading to a protein truncation prior to the BH3 and transmemebrane domains. The absence of protein product was confirmed by western blot analysis. (J:127533)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bnip3 Mutation: 24 strains or lines available

References

• Original: J:127533 Diwan A, et al., Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. J Clin Invest. 2007 Oct;117(10):2825-33
• All: 14 reference(s)