Tg(Myh6/tetO-BNIP3)1Gwd
Transgene Detail

Summary

• Symbol: Tg(Myh6/tetO-BNIP3)1Gwd
• Name: transgene insertion 1, Gerald W Dorn II
• MGI ID: MGI:3764670
• Synonyms: alphaMHCminTetOBnip3
• Transgene: Tg(Myh6/tetO-BNIP3)1Gwd Location: unknown
• Alliance: Tg(Myh6/tetO-BNIP3)1Gwd page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: A tetracycline-responsive Myh6 promoter was fused to a cDNA encoding human BNIP3. Immunoreactivity following activation of this transgene is increased 50-fold without changing the relative abundance of major cardiac anti-apoptotic Bcl2 family proteins. (J:127533)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127533 Diwan A, et al., Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. J Clin Invest. 2007 Oct;117(10):2825-33
• All: 1 reference(s)