Cyp26b1^tm1Ptk
Targeted Allele Detail

Summary

• Symbol: Cyp26b1^tm1Ptk
• Name: cytochrome P450, family 26, subfamily b, polypeptide 1; targeted mutation 1, Martin Petkovich
• MGI ID: MGI:3764691
• Synonyms: Cyp26b1^fl, L3
• Gene: Cyp26b1 Location: Chr6:84548396-84570890 bp, - strand Genetic Position: Chr6, 36.45 cM
• Alliance: Cyp26b1^tm1Ptk page

Loss of germ cells in adult Cyp26b1^tm1Ptk/Cyp26b1^tm1Ptk Plekha5^{Tg(AMH-cre)1Flor}/0 animals

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126705
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A single loxP site was inserted 5' to exon 3 and a loxP flanked neomycin selection cassette was inserted 3' to exon 6. (J:126705)

Generation of the Cyp26b1^tm1Ptk allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp26b1 Mutation: 35 strains or lines available

References

• Original: J:126705 MacLean G, et al., Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice. Endocrinology. 2007 Oct;148(10):4560-7
• All: 6 reference(s)