Cyp26b1^tm1.1Ptk
Targeted Allele Detail

Summary

• Symbol: Cyp26b1^tm1.1Ptk
• Name: cytochrome P450, family 26, subfamily b, polypeptide 1; targeted mutation 1.1, Martin Petkovich
• MGI ID: MGI:3764694
• Synonyms: Cyp26b1^-
• Gene: Cyp26b1 Location: Chr6:84548396-84570890 bp, - strand Genetic Position: Chr6, 36.45 cM
• Alliance: Cyp26b1^tm1.1Ptk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126705
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This heritable allele is a derivative of Cyp26b1^tm1Ptk in which the loxP flanked sequences, including exons 2-6 and the neomycin cassette, were deleted by breeding heterozygous mice to mice carrying cre recombinase. (J:126705)

Expression

In Mice Carrying this Mutation:	96 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp26b1 Mutation: 35 strains or lines available

References

• Original: J:126705 MacLean G, et al., Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice. Endocrinology. 2007 Oct;148(10):4560-7
• All: 3 reference(s)