Tg(Pf4-icre)Q3Rsko
Transgene Detail

Summary

• Symbol: Tg(Pf4-icre)Q3Rsko
• Name: transgene insertion Q3, Radek C Skoda
• MGI ID: MGI:3764698
• Synonyms: Pf4-Cre, (Pf4)-Cre, Tg(Cxcl4-cre)Q3Rsko, Tg(Pf4-cre)Q3Rsko
• Transgene: Tg(Pf4-icre)Q3Rsko Location: unknown
• Alliance: Tg(Pf4-icre)Q3Rsko page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pf4-icre)Q3Rsko expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Pf4

• Mutation details: A transgene was created from a BAC where cre-recombinase is driven by the Cxcl4 (Platelet factor 4) promoter. This transgene also contains the Cxcl3, Cxcl5, Ppbp, and Cxcl15 genes. This line has one copy of the transgene inserted with expression restricted to megakaryocytes and platelets, as demonstrated by RT-PCR and Western blotting. (J:127229)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pf4 (species not specified) Summary of all recombinase alleles driven by Pf4. Comparative matrix view of recombinase activities

Disease models

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:127229 Tiedt R, et al., Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. Blood. 2007 Feb 15;109(4):1503-6
• All: 309 reference(s)