Nr2e1^tm2Gsc
Targeted Allele Detail

Summary

• Symbol: Nr2e1^tm2Gsc
• Name: nuclear receptor subfamily 2, group E, member 1; targeted mutation 2, Gunther Schutz
• MGI ID: MGI:3764730
• Synonyms: tlx^flox
• Gene: Nr2e1 Location: Chr10:42437959-42459628 bp, - strand Genetic Position: Chr10, 22.89 cM
• Alliance: Nr2e1^tm2Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127237
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites and an FRT-flanked neo cassette was inserted. The FRT-flanked neo cassette was removed by a subsequent cross to Tg(ACTFLPe)9205Dym mice. (J:127237)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr2e1 Mutation: 32 strains or lines available

References

• Original: J:127237 Belz T, et al., Inactivation of the gene for the nuclear receptor tailless in the brain preserving its function in the eye. Eur J Neurosci. 2007 Oct;26(8):2222-7
• All: 4 reference(s)