Gdf3^{Gt(AD0857)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Gdf3^{Gt(AD0857)Wtsi}
• Name: growth differentiation factor 3; gene trap AD0857, Wellcome Trust Sanger Institute
• MGI ID: MGI:3764814
• Synonyms: Gdf3^-
• Gene: Gdf3 Location: Chr6:122582362-122587046 bp, - strand Genetic Position: Chr6, 57.7 cM
• Alliance: Gdf3^{Gt(AD0857)Wtsi} page

Mutation origin

• Mutant Cell Line: AD0857
• Germline Transmission: Earliest citation of germline transmission: J:127541
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• Mutation details: A genetrap vector consisting of a splice acceptor site and a single loxP site upstream of a frt flanked beta-geo cassette inserted into the only intron of the gene. No gene expression was detected in homozygous embryos or adult spleen tissue by RT-PCR. (J:127541)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AD0857	CL459123 ; (MGI Seq Detail)	5' RACE	Chr6:122586654-122586836 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  29 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf3 Mutation: 40 strains or lines available

References

• Original: J:127541 Andersson O, et al., Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol. 2007 Nov 15;311(2):500-11
• All: 2 reference(s)