Tg(Cryaa-TAg)7488Lmgd
Transgene Detail

Summary

• Symbol: Tg(Cryaa-TAg)7488Lmgd
• Name: transgene insertion 7488, Laboratory of Mammalian Genes and Development, Heiner Westphal
• MGI ID: MGI:3764829
• Synonyms: a-crys-Tag, alpha-crys-Tag
• Transgene: Tg(Cryaa-TAg)7488Lmgd Location: unknown
• Alliance: Tg(Cryaa-TAg)7488Lmgd page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgenic construct consists of 416 bp of the 5' flanking sequence from the murine alpha-A crystallin gene (Cryaa) fused to the coding sequence of the SV40 early region. Transgenic F0 animals generally died prematurely by 4 months of age so only one line, 7488, bearing 2 copies of the transgene, was propagated. Expression is lens-specific. Transgene expression is identified by white and opaque appearance of the eyes upon opening, instead of a normal transparent lens. (J:127709)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Cryaa-TAg)7488Lmgd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127709 Mahon KA, et al., Oncogenesis of the lens in transgenic mice. Science. 1987 Mar 27;235(4796):1622-8
• All: 1 reference(s)