About   Help   FAQ
Epm2aTg(TcraK,TcrbK)TG-BFlv
Transgenic Allele Detail
Summary
Symbol: Epm2aTg(TcraK,TcrbK)TG-BFlv
Name: epilepsy, progressive myoclonic epilepsy, type 2 gene alpha; transgene insertion TG-B, Richard A Flavell
MGI ID: MGI:3764832
Synonyms: H2-Kk, TG-B, Tg(TcraK,TcrbK)TG-BFlv
Gene: Epm2a  Location: Chr10:11219148-11335388 bp, + strand  Genetic Position: Chr10, 3.66 cM, cytoband A
Alliance: Epm2aTg(TcraK,TcrbK)TG-BFlv page
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA/J)F2
Transgene
description
Transgene Type:    Transgenic (Hypomorph, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgenic mice express rearranged Valpha and Vbeta genes from a CTL clone that recognized the SV40 large T antigen (SV-T). The V and J regions of a transgene construct (made in J:107523) were replaced with the V and J regions of the clone K T cell receptor. The synthetic alpha and beta constructs were coinjected into 1 day embryos. Three lines were obtained and line TG-B was further characterized. The transgene in line TG-B inserted into intron 1. Western blot analysis confirmed reduced protein expression. (J:107545, J:112696)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epm2a Mutation:  28 strains or lines available
References
Original:  J:107545 Geiger T, et al., T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2985-9
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory