Sln^tm1Peri
Targeted Allele Detail

Summary

• Symbol: Sln^tm1Peri
• Name: sarcolipin; targeted mutation 1, Muthu Periasamy
• MGI ID: MGI:3764910
• Synonyms: sln^-
• Gene: Sln Location: Chr9:53757535-53761133 bp, + strand Genetic Position: Chr9, 29.24 cM, cytoband C
• Alliance: Sln^tm1Peri page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127150
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence, contained within exon 2, was replaced with a PGK-neo cassette. The absence of transcript and protein production was confirmed by RT-PCR and western blot analysis, respectively, using atria and ventricle tissue. (J:127150)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sln Mutation: 11 strains or lines available

References

• Original: J:127150 Babu GJ, et al., Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility. Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17867-72
• All: 21 reference(s)