Mex3c^{Gt(DD0642)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Mex3c^{Gt(DD0642)Wtsi}
• Name: mex3 RNA binding family member C; gene trap DD0642, Wellcome Trust Sanger Institute
• MGI ID: MGI:3764947
• Synonyms: Mex3c^tr
• Gene: Mex3c Location: Chr18:73706115-73725646 bp, + strand Genetic Position: Chr18, 49.29 cM
• Alliance: Mex3c^{Gt(DD0642)Wtsi} page

Mutation origin

• Mutant Cell Line: DD0642
• Germline Transmission: Earliest citation of germline transmission: J:189503
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1lxrT2
• The gene trap vector inserted into intron 2. qRT-PCR confirmed the absence of transcript expression. (J:189503)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  DD0642	DU636425 ; (MGI Seq Detail)	5' RACE	Chr18:73706549-73706846 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  1 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mex3c Mutation: 20 strains or lines available

References

• Original: J:189503 Jiao Y, et al., Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth. Mol Biol Cell. 2012 Apr;23(8):1404-13
• All: 4 reference(s)