Mc2r^tm1Dchi
Targeted Allele Detail

Summary

• Symbol: Mc2r^tm1Dchi
• Name: melanocortin 2 receptor; targeted mutation 1, Dai Chida
• MGI ID: MGI:3764974
• Synonyms: MC2R^-
• Gene: Mc2r Location: Chr18:68539978-68562391 bp, - strand Genetic Position: Chr18, 41.89 cM
• Alliance: Mc2r^tm1Dchi page

Histological analysis of the adrenal gland of Mc2r^tm1Dchi/Mc2r^tm1Dchi mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127445
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region contained within exon 4 was replaced with a PGK-neo cassette. RT-PCR confirmed the absence of transcript in extracts from the adrenal gland. (J:127445)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mc2r Mutation: 23 strains or lines available

References

• Original: J:127445 Chida D, et al., Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18205-10
• All: 7 reference(s)