Vasp^tm1Ref
Targeted Allele Detail

Summary

• Symbol: Vasp^tm1Ref
• Name: vasodilator-stimulated phosphoprotein; targeted mutation 1, Reinhard Fassler
• MGI ID: MGI:3764987
• Synonyms: vv
• Gene: Vasp Location: Chr7:18990854-19005742 bp, - strand Genetic Position: Chr7, 9.51 cM, cytoband A2
• Alliance: Vasp^tm1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51905
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A promoterless lacZ-neo fusion gene lacking the first two amino acids and contianing the bovine growth horone poly A signal was inserted into exon 2 replacing exons 2 through 13. The lack of protein expresison was confirmed by western blot analysis on protein extracted from platelets, liver and the duodenum. (J:51905)

Expression

In Mice Carrying this Mutation:

16 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vasp Mutation: 38 strains or lines available

References

• Original: J:51905 Aszodi A, et al., The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. EMBO J. 1999 Jan 4;18(1):37-48
• All: 11 reference(s)