Myt1^tm1Ggu
Targeted Allele Detail

Summary

• Symbol: Myt1^tm1Ggu
• Name: myelin transcription factor 1; targeted mutation 1, Guoqiang Gu
• MGI ID: MGI:3765054
• Synonyms: Myt1^f
• Gene: Myt1 Location: Chr2:181405125-181469590 bp, + strand Genetic Position: Chr2, 103.77 cM
• Alliance: Myt1^tm1Ggu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127471
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A FRT flanked pGK-Neo cassette and a loxP site was inserted upstream of exon 9 (or exon 3 when the short alternative transcript is being produced) and a third loxP site was inserted downstream of the exon. Mice were crossed with a Flpe deleter strain to remove the selection cassette, leaving the targeted exon flanked by loxP sites with one FRT site remaining upstream of the targeted exon but downstream of the first loxP site. (J:127471)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myt1 Mutation: 57 strains or lines available

References

• Original: J:127471 Wang S, et al., Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007 Nov-Dec;124(11-12):898-910
• All: 2 reference(s)