Myt1^tm1.1Ggu
Targeted Allele Detail

Summary

• Symbol: Myt1^tm1.1Ggu
• Name: myelin transcription factor 1; targeted mutation 1.1, Guoqiang Gu
• MGI ID: MGI:3765056
• Gene: Myt1 Location: Chr2:181405125-181469590 bp, + strand Genetic Position: Chr2, 103.77 cM
• Alliance: Myt1^tm1.1Ggu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127471
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Myt1^tm1Ggu mice were crossed with Tg(Sox2-cre)1Amc mice, excising the floxed exon (exon 9 for long transcript of gene, exon 3 for short transcript) in the germline. Inactivation of the gene was confirmed by ISH and RT-PCR of the pancreas in E18.5 embryos. (J:127471)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	82 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myt1 Mutation: 57 strains or lines available

References

• Original: J:127471 Wang S, et al., Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007 Nov-Dec;124(11-12):898-910
• All: 1 reference(s)