Fasn^tm1Sem
Targeted Allele Detail

Summary

• Symbol: Fasn^tm1Sem
• Name: fatty acid synthase; targeted mutation 1, Clay F Semenkovich
• MGI ID: MGI:3765070
• Synonyms: Fas^f
• Gene: Fasn Location: Chr11:120696672-120715373 bp, - strand Genetic Position: Chr11, 84.56 cM
• Alliance: Fasn^tm1Sem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127793
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP flanked neo cassette was placed upstream of exon 4 and a third loxP site was placed downstream of exon 8. Insertion of targeting vector was verified by Southern blotting. (J:127793)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fasn Mutation: 89 strains or lines available

References

• Original: J:127793 Chakravarthy MV, et al., 'New' hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab. 2005 May;1(5):309-22
• All: 33 reference(s)