Tg(Hmgcr-MX1)LStae
Transgene Detail

Summary

• Symbol: Tg(Hmgcr-MX1)LStae
• Name: transgene insertion L, Peter Staeheli
• MGI ID: MGI:3765440
• Synonyms: MxA-transgenic, tg-MxA
• Transgene: Tg(Hmgcr-MX1)LStae Location: unknown
• Alliance: Tg(Hmgcr-MX1)LStae page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Hmgcr-MX1)LStae expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MX1 (4599)

  Mx1	(MGI:97243)
  Mx2	(MGI:97244)

• Mutation details: Human cDNA encoding the cytoplasmic protein MX1 was put under the control of the murine Hmgcr promoter. Founder mice were generated with on a genetic background that lacks functional Mx1 and Mx2 genes. Transgenic mice expressed protein in the brain, heart, kidney, spleen, thymus, and lung. (J:128067)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Two founder lines were generated, "G" and "L". The only observed difference between the two lines is that breeding of the "G" line did not yield homozygous females.

References

• Original: J:128067 Pavlovic J, et al., Enhanced virus resistance of transgenic mice expressing the human MxA protein. J Virol. 1995 Jul;69(7):4506-10
• All: 3 reference(s)