Ncor2^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Ncor2^tm1Rsd
• Name: nuclear receptor co-repressor 2; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:3765904
• Synonyms: SMRT^-
• Gene: Ncor2 Location: Chr5:125094217-125256283 bp, - strand Genetic Position: Chr5, 63.96 cM, cytoband F
• Alliance: Ncor2^tm1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127720
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2 kb region containing 4 exons that encode amino acids 1038 to 1198 was replaced with a beta-globin/PGK-neo cassette. The absence of protein product was confirmed by western blot analysis. (J:127720)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ncor2 Mutation: 170 strains or lines available

References

• Original: J:127720 Jepsen K, et al., SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature. 2007 Nov 15;450(7168):415-9
• All: 3 reference(s)