Fbxl20^tm1Seto
Targeted Allele Detail

Summary

• Symbol: Fbxl20^tm1Seto
• Name: F-box and leucine-rich repeat protein 20; targeted mutation 1, Mitsutoshi Setou
• MGI ID: MGI:3765911
• Gene: Fbxl20 Location: Chr11:97973382-98041229 bp, - strand Genetic Position: Chr11, 61.69 cM
• Alliance: Fbxl20^tm1Seto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127941
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 and part of exon 4 were replaced by a neo cassette resulting in the loss of the F-box domain and a frame shift. The loss of protein product was confirmed by western blot analysis on hippocampus extracts. (J:127941)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbxl20 Mutation: 33 strains or lines available

References

• Original: J:127941 Yao I, et al., SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell. 2007 Sep 7;130(5):943-57
• All: 4 reference(s)