Sarm1^tm1Aidi
Targeted Allele Detail

Summary

• Symbol: Sarm1^tm1Aidi
• Name: sterile alpha and HEAT/Armadillo motif containing 1; targeted mutation 1, Aihao Ding
• MGI ID: MGI:3765956
• Synonyms: MyD88-5^-
• Gene: Sarm1 Location: Chr11:78363156-78388580 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Sarm1^tm1Aidi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126083
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 6 were replaced with a neo cassette in reverse orientation. The absence of protein product was confirmed by western blot analysis on protein extracted from the brain. (J:126083)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sarm1 Mutation: 25 strains or lines available

References

• Original: J:126083 Kim Y, et al., MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. J Exp Med. 2007 Sep 3;204(9):2063-74
• All: 54 reference(s)