Gprc5a^tm1Rlo
Targeted Allele Detail

Summary

• Symbol: Gprc5a^tm1Rlo
• Name: G protein-coupled receptor, family C, group 5, member A; targeted mutation 1, Reuben Lotan
• MGI ID: MGI:3765976
• Gene: Gprc5a Location: Chr6:135042660-135061707 bp, + strand Genetic Position: Chr6, 65.83 cM
• Alliance: Gprc5a^tm1Rlo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127821
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-4 were replaced with a LacZ gene and a loxP-flanked neomycin resistance cassette. Endogenous gene expression was not detected in the lung of homozygotes by RT-PCR. LacZ activity was detected in epithelial cells of the lungs. (J:127821)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gprc5a^tm1Rlo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gprc5a Mutation: 48 strains or lines available

References

• Original: J:127821 Tao Q, et al., Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene. J Natl Cancer Inst. 2007 Nov 21;99(22):1668-82
• All: 21 reference(s)