Scn5a^tm1Clhh
Targeted Allele Detail

Summary

• Symbol: Scn5a^tm1Clhh
• Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 1, Christopher LH Huang
• MGI ID: MGI:3765977
• Synonyms: Scn5a^delta
• Gene: Scn5a Location: Chr9:119312474-119408082 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Scn5a^tm1Clhh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127879
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: A 9 bp deletion (deleting amino acids lysine, proline and glutamine; deltaKPQ) was introduced into exon 26. A floxed thymidine kinase and neo cassette was also inserted into intron 26 but was removed by cre-mediated recombination using a cre recombinase expressing vector. Modification to the transcript was confirmed by RT-PCR. (J:127879)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn5a Mutation: 105 strains or lines available

References

• Original: J:127879 Head CE, et al., Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice. J Cardiovasc Electrophysiol. 2005 Dec;16(12):1329-40
• All: 4 reference(s)