Tg(PLA2G2A)703Dsg
Transgene Detail

Summary

• Symbol: Tg(PLA2G2A)703Dsg
• Name: transgene insertion 703, David S Grass
• MGI ID: MGI:3766007
• Synonyms: PLA2+
• Transgene: Tg(PLA2G2A)703Dsg Location: unknown
• Alliance: Tg(PLA2G2A)703Dsg page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PLA2G2A)703Dsg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PLA2G2A (5320)

  Pla2g2a

  (MGI:104642)

• Mutation details: The transgene contains the open reading frame of human PLA2G2A including 1.6 Kb upstream of the RNA inititation site and 0.35 Kb of the nucleotides downstream of the polyadenylation signal sequence. (J:113573)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

4 of 10 founder animals were used to create lines (854, 703, 713, and 719). Line 703 has 2 copies of the transgene with the highest level of expression and was chosen as the representative lines.

References

• Original: J:113573 Grass DS, et al., Expression of human group II PLA2 in transgenic mice results in epidermal hyperplasia in the absence of inflammatory infiltrate. J Clin Invest. 1996 May 15;97(10):2233-41
• All: 16 reference(s)