Tg(Ins2-H2-Ea^d,Ins2-H2-Eb1^b)187-7Bri
Transgene Detail

Summary

• Symbol: Tg(Ins2-H2-Ea^d,Ins2-H2-Eb1^b)187-7Bri
• Name: transgene insertion 187-7, Ralph L Brinster
• MGI ID: MGI:3766019
• Synonyms: I-E, Ins-IE, Insl-E
• Transgene: Tg(Ins2-H2-Ea^d,Ins2-H2-Eb1^b)187-7Bri Location: unknown
• Alliance: Tg(Ins2-H2-Ea^d,Ins2-H2-Eb1^b)187-7Bri page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-H2-Ea^d,Ins2-H2-Eb1^b)187-7Bri expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H2-Ea (MGI:95900)
  mouse	H2-I (MGI:95903)

• Mutation details: 2 independent constructs consisting of a 600 bp fragment of the 5' sequences driving the H2-Ea^d and a 600 bp fragment of 5' sequence driving the H2-Eb1^b gene were coinjected into fertilized pronuclei. Four founders with germline transmission were identified and 3 (187-1, 187-7, and 190-5) were further studied. 187-7 (male) was chosen as representative, since it apparently characterized most thoroughly. (J:127706)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127706 Lo D, et al., Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell. 1988 Apr 8;53(1):159-68
• All: 3 reference(s)