Tg(COL1A1)73Prc
Transgene Detail

Summary

• Symbol: Tg(COL1A1)73Prc
• Name: transgene insertion 73, Darwin J Prockop
• MGI ID: MGI:3766089
• Synonyms: line V
• Transgene: Tg(COL1A1)73Prc Location: unknown
• Alliance: Tg(COL1A1)73Prc page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(COL1A1)73Prc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  COL1A1 (1277)

  Col1a1

  (MGI:88467)

• Mutation details: These mice express a mini-gene construct that contains the 5'- and 3'-ends of the human gene for the pro-alpha(1) collagen chain but lack a large central region containing 41 exons. The mini-gene includes 2.5 kilobases of the 5'-promoter region, the first 5 exons and introns, the last 6 exons and introns, and about 2 kilobases of the 3"flanking region. The junction between the 5'- and 3'-halves of the mini-gene was made in introns so as to preserve the consensus sequences for RNA splicing. Mice in this line carry about 20 copies of the transgene. (J:31417, J:146429)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:31417 Khillan JS, et al., Transgenic mice that express a mini-gene version of the human gene for type I procollagen (COL1A1) develop a phenotype resembling a lethal form of osteogenesis imperfecta. J Biol Chem. 1991 Dec 5;266(34):23373-9
• All: 6 reference(s)