Tg(Or10j5-Or6a2*,-EYFP)1Hsak
Transgene Detail

Summary

• Symbol: Tg(Or10j5-Or6a2*,-EYFP)1Hsak
• Name: transgene insertion 1, Hitoshi Sakano
• MGI ID: MGI:3766291
• Synonyms: 17(RDY)-IRES-EYFP, I7(RDY), I7-RDY-IRES-YFP, Tg(Olfr16-Olfr2*,-YFP)1Hsak
• Transgene: Tg(Or10j5-Or6a2*,-EYFP)1Hsak Location: unknown
• Alliance: Tg(Or10j5-Or6a2*,-EYFP)1Hsak page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene puts the rat Olfr2 gene under the control of the mouse Olfr16 promoter. In the rat Olfr2 gene, the DRY motif at the cytoplasmic end of the transmembrane domain III was mutated to RDY. It was predicted this mutation would prevent association of G proteins involved in downstream signaling. An enhanced yellow fluorescent protein (YFP) reporter gene was also inserted downstream of the rat gene. YFP expression is observed in zone 1 of the olfactory epithelium of transgenic mice. (J:128070)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128070 Imai T, et al., Odorant receptor-derived cAMP signals direct axonal targeting. Science. 2006 Oct 27;314(5799):657-61
• All: 6 reference(s)