Tg(Myh6-Map2k1*)1Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6-Map2k1*)1Jmol
• Name: transgene insertion 1, Jeffery D Molkentin
• MGI ID: MGI:3766499
• Synonyms: MEK1, MEK1 TG
• Transgene: Tg(Myh6-Map2k1*)1Jmol Location: unknown
• Alliance: Tg(Myh6-Map2k1*)1Jmol page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Map2k1*)1Jmol expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Map2k1 (MGI:1346866)

• Mutation details: A Map2k1 gene that encodes a constitutively active protein by substituting glutamines for serines 217 and 221 was put under the control of the cardiac specific Myh6 promoter. Nine independent lines were created with transgene copy number ranging from 2 to over 40. Transgene expression was detected in heart muscle at levels 3.9 to 6.3 fold higher than expression of endogenous Map2k1. This is a representative record for all lines. (J:66102)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:66102 Bueno OF, et al., The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J. 2000 Dec 1;19(23):6341-50
• All: 9 reference(s)