Del(11Mpo-Chad)18Brd
Targeted Allele Detail

Summary

• Symbol: Del(11Mpo-Chad)18Brd
• Name: deletion, Chr 11, Bradley 18; deletion, Chr 11, Allan Bradley 18
• MGI ID: MGI:3766573
• Synonyms: Del18Brd, Df(11)18
• Gene: Del(11Mpo-Chad)18Brd Location: Chr11:87684610-94459953 bp Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109163
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(11Mpo-Chad)18Brd involves 100 genes/genome features (n-R5s72, Gm22702, Gm11499 ...) View all
• Mutation details: A loxP site was targeted into the Mpo gene. A second loxP site was targeted in trans into the Chad gene. Transient expression of Cre recombinase in ES cells resulted in recombination between loxP sites on opposite chromosomes, deleting the 6.9 Mb region from Mpo to Chad. (J:109163)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(11Mpo-Chad)18Brd Mutation: 0 strains or lines available

References

• Original: J:109163 Yu YE, et al., A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice. Genetics. 2006 May;173(1):297-307
• All: 1 reference(s)