Del(11Chad-Hoxb1)19Brd
Targeted Allele Detail

Summary

• Symbol: Del(11Chad-Hoxb1)19Brd
• Name: deletion, Chr 11, Bradley 19; deletion, Chr 11, Allan Bradley 19
• MGI ID: MGI:3766574
• Synonyms: Del19Brd, Df(11)19
• Gene: Del(11Chad-Hoxb1)19Brd Location: Chr11:94455900-96259082 bp Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109163
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(11Chad-Hoxb1)19Brd involves 92 genes/genome features (Gm27605, Gm24877, Gm26830 ...) View all
• Mutation details: A loxP site was targeted into the Chad gene. A second loxP site was targeted in cis into the Hoxb1 gene. Transient expression of Cre recombinase in ES cells resulted in recombination between loxP sites on the same chromosome, deleting the 1.8 Mb region from Chad to Hoxb1. (J:109163)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(11Chad-Hoxb1)19Brd Mutation: 0 strains or lines available

References

• Original: J:109163 Yu YE, et al., A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice. Genetics. 2006 May;173(1):297-307
• All: 1 reference(s)